Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
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Scalable and unbiased sequence-informed embedding of single-cell ATAC-seq data with CellSpace

Nature Methods, Published online: 09 May 2024; doi:10.1038/s41592-024-02274-xBy learning to embed DNA k-mers and cells into a joint space, CellSpace improves single-cell ATAC-seq analysis in multiple tasks such as latent structure discovery, transcription factor activity inference and batch effect mitigation.

Thu May 9, 2024 12:41
Multiplex profiling of developmental <i>cis-</i>regulatory elements with quantitative single-cell expression reporters

Nature Methods, Published online: 09 May 2024; doi:10.1038/s41592-024-02260-3Single-cell quantitative expression reporters enable high-sensitivity quantitative characterization of cis-regulatory elements at the single-cell level in multicellular systems.

Thu May 9, 2024 12:41
Molecular pixelation: spatial proteomics of single cells by sequencing

Nature Methods, Published online: 08 May 2024; doi:10.1038/s41592-024-02268-9Molecular Pixelation is an optics-free method that uses DNA-tagged antibodies to enable identification of the relative location of proteins on single cells.

Wed May 8, 2024 13:40
Author Correction: brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Nature Methods, Published online: 07 May 2024; doi:10.1038/s41592-024-02296-5Author Correction: brainlife.io: a decentralized and open-source cloud platform to support neuroscience research

Tue May 7, 2024 19:11
Decoding immune kinetics: unveiling secrets using custom-built mathematical models

Nature Methods, Published online: 06 May 2024; doi:10.1038/s41592-024-02265-yCustom-built mathematical models make the immune response more predictable and offer mechanistic insights into fundamental immunology.

Mon May 6, 2024 13:22
A genome-scale approach for determining the function of phosphorylation sites

Nature Methods, Published online: 30 April 2024; doi:10.1038/s41592-024-02264-zCombining post-translational modification site-centric base editing with phenotypic screens uncovers the function of phosphorylation sites in high throughput, enabling the study of expansive signaling networks at a speed comparable to that of functional genomics.

Wed May 1, 2024 06:36

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