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[Articles] Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization

Since 1974 substantial gains in childhood survival have occurred in every global region. We estimate that EPI has provided the single greatest contribution to improved infant survival over the past 50 years. In the context of strengthening primary health care, our results show that equitable universal access to immunisation remains crucial to sustain...

Fri May 3, 2024 02:28
[Articles] Ibrutinib combined with immunochemotherapy with or without autologous stem-cell transplantation versus immunochemotherapy and autologous stem-cell transplantation in previously untreated patients with mantle cell lymphoma (TRIANGLE): a three-arm, randomised, open-label, phase 3 superiority trial of the European Mantle Cell Lymphoma Network

Adding ibrutinib to first-line treatment resulted in superior efficacy in younger mantle cell lymphoma patients with increased toxicity when given after ASCT. Adding ibrutinib during induction and as maintenance should be part of first-line treatment of younger mantle cell lymphoma patients. Whether ASCT adds to an ibrutinib-containing regimen is not...

Fri May 3, 2024 02:28
[Comment] The evolving profile of eating disorders and their treatment in a changing and globalised world

It has been more than 70 years since the first eating disorder, anorexia nervosa, was included in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Since then, recognition of a spectrum of disorders with eating difficulties has grown.1 We draw on academic, clinical, and lived experience expertise to identify two inter-related challenges...

Fri May 3, 2024 02:28
[Comment] Does TRIANGLE take down transplantation in mantle cell lymphoma?

Autologous stem-cell transplantation (ASCT) is considered the standard of care for management of younger patients (ie, younger than 65–70 years) with newly diagnosed mantle cell lymphoma in much of the world. Once associated with a poor overall survival (only 2 years in many reports), mantle cell lymphoma has been the subject of increasingly intense...

Fri May 3, 2024 02:28
[Correspondence] Patients in Gaza with chronic conditions need urgent interventions

The protracted conflict in Gaza has profound repercussions on the health of its residents, particularly those managing chronic conditions, such as diabetes and hypertension. We aim to highlight the struggles of these unaccounted victims of war and the compounded challenges they face due to medication scarcity and disruptions in primary health-care facilities....

Thu May 2, 2024 01:39
[Comment] Collective action and legal mobilisation for the right to health in the climate crisis

2024 is the year of international climate change litigation, with accountability for the protection of health elevated to global and regional courts and tribunals. On April 9, 2024, the European Court of Human Rights concluded that Switzerland violated the rights of a group of older Swiss women, known as the KlimaSeniorinnen Schweiz, who had brought...

Thu May 2, 2024 01:39

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