by Zheng Yuan, Mark F. van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J. Smith, David C. S. Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A. Smith, Richard W. Birkinshaw, Peter E. Czabotar, Grant Dewson BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated...

by Xiao Gan, Palanivelu Sengottaiyan, Kyu Hyong Park, Sarah M. Assmann, Réka Albert Stomata are pores on plant aerial surfaces, each bordered by a pair of guard cells. They control gas exchange vital for plant survival. Understanding how guard cells respond to environmental signals such as atmospheric carbon dioxide (CO2) levels is not only insightful...

by Kevin H-C. Wei, Kamalakar Chatla, Doris Bachtrog Although sex chromosomes have evolved from autosomes, they often have unusual regulatory regimes that are sex- and cell-type-specific such as dosage compensation (DC) and meiotic sex chromosome inactivation (MSCI). The molecular mechanisms and evolutionary forces driving these unique transcriptional...

by Lorenzo Gaifas, Moritz A. Kirchner, Joanna Timmins, Irina Gutsche Powerful, workflow-agnostic and interactive visualisation is essential for the ad hoc, human-in-the-loop workflows typical of cryo-electron tomography (cryo-ET). While several tools exist for visualisation and annotation of cryo-ET data, they are often integrated as part of monolithic...

by Abdallah M. Eteleeb, Brenna C. Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joseph Bradley, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A. Davis, John C. Morris, Celeste M. Karch, Richard J. Perrin, Bruno A. Benitez, Oscar Harari Unbiased...

by Jacob Gordon, Robin E. Stanley The 3′ end of the 18S ribosomal RNA is formed by the endoribonuclease Nob1. How cells ensure the accuracy of the 3′ end has remained a mystery. A new study in PLOS Biology revealed that there are multiple checkpoints to ensure that only ribosomes containing the correct 3′ end participate in translation. The...