Cell membrane-targeting type I/II PS (TBzT-CNQi) combination with FSP1 inhibitor to downregulate FSP1 expression, lower the intracellular CoQ10 content, induce a high level of LPO, activate ferroptosis, and amplify ferroptosis-enhanced photodynamic immunotherapy is presented. Abstract An imbalance in reactive oxygen species (ROS) levels in...

Integrating sensing in bionic organoids allows to monitor deformation locally within engineered soft tissues. Multi-material bioprinting enables the fabrication of bionic organoids with a discrete interface between soft tissue and sensing ink, allowing the transfer of loads from contracting tissue to the sensing phase. Higher cell viability and preserved...

Abstract Hypoxia, a ubiquitous hallmark in cancer, underscores the significance of targeting HIF-1α, the principal transcriptional factor of hypoxic responses, for effective cancer therapy. Herein, we introduce DNA yokes, a novel class of DNA nanomaterials harboring specific HIF-1α binding sequences (hypoxia response elements, HREs), as nano-pharmaceuticals...

Abstract Inorganic nanoparticles are promising materials for bone tissue engineering due to their chemical resemblance to the native bone structure. However, most studies were unable to capture the entirety of the defective environment, providing limited bone regenerative abilities. Hence, this study aims to develop a multifunctional nanoparticle to...

Intelligent polymersomal nanovaccines (PNVs) are developed to quantitatively coload, efficiently codeliver, and responsively corelease tumor cell lysates and CpG adjuvant to lymph node (LN) dendritic cells. These LN-directed PNVs boost antigen presentation and induce specific and robust antitumor immunity. PNVs are highly versatile and open a new...

Using computational fluid dynamics (CFD) allows the optimization of bioprinting by analyzing flow velocity, shear stress, and pressure distribution, which enhances the printability, nozzle design, and bioink formulations for tissue construction. CFD enhances bioink deposition and cell viability while reducing the need for repetitive experiments, curbing...