A series of NIR-IIa emissive dibenzofluoran-based polymer dots are successfully synthesized. The properties of these molecules are fully studied and the bio-applications of these polymer dots including 3D vasculature imaging are also demonstrated. Abstract Emerging organic molecules with emissions in the second near-infrared (NIR-II) region...

The IR-808 and Nd3+ co-conjugated polymer NIR-II fluoroprobes with twisted intramolecular charge transfer state and Förster resonance energy transfer process are demonstrated for boosting NIR-II tail emission. The probes with rapid renal clearance are employed for angiography, middle cerebral artery occlusion mice imaging, and prognosis of acute kidney...

This work introduces the role of peptides in immune regulation of innate and adaptive immune cells, as well as immune checkpoints. Then this work introduces two strategies for delivering polypeptides: peptide self-assemblies, and peptide-functionalized nanocarriers. Finally, the challenges and prospects of peptides in tumor immunotherapy are summarized....

Fibrosis is a condition shared by multiple disorders, and affecting virtually any organ. It is primarily characterized by excessive extracellular matrix (ECM) deposition, ultimately leading to organ dysfunction and/or failure. This review discusses fibrosis, from the viewpoint of developing organ-on-chip models, focusing on five key features: the...

Highly porous microspheres containing barium sulfate are produced and then cellularized with bioluminescent mesenchymal stem cells to permit detection using X-ray CT and optical imaging. Injectable microspheres are delivered in a minimally invasive manner under ultrasound guidance. This multi-modal imaging approach allows co-localization of cells...

By virtue of glycometabolic engineering and bio-orthogonal reaction, endogenous polysialic acid is used to form a mesh-like network of glycan matrix on the cell membrane, and the altered glycan matrix alleviates the stimulation and induction effect of cytokines on tumor cells and inhibits tumor metastasis. Abstract This work reports a new...