Abstract Bacterial infection, inflammation, and excessive oxidative stress are the primary factors that contribute to delayed healing of skin wounds. In this study, a multifunctional wound dressing (SF/Ag@rGO hydrogel) is developed to promote the healing of infected skin wounds by combining the inherent antibacterial activity of Ag nanoparticles (NPs)...

Abstract The exploration of sonodynamic therapy (SDT) as a possible replacement for antibiotics in antibacterial treatment by creating reactive oxygen species (ROS) has been suggested as a non-drug-resistant theranostic method. However, the low-efficiency ROS generation and complex tumor microenvironment (TME) which can deplete ROS and promote tumor...

Abstract Background: The uptake of large (>10 nm) non-targeted nanocarriers by bulk tumors is thought to be dominated by passive extravasation through porous tumor vessels and limited lymphatic drainage, the enhanced permeability and retention (EPR) effect. Prior studies demonstrated radiolabeled tumor-targeted and non-targeted 4-arm 40 kDa star...

Polymeric carriers are engineered for covalent conjugation of oligonucleotide agonists of retinoic acid-inducible gene I (RIG-I) and chemical design criteria for optimizing their immunostimulatory activity are established. Abstract RNA ligands of retinoic acid-inducible gene I (RIG-I) are a promising class of oligonucleotide therapeutics...

A biomimetic wicking-evaporation fabric inspired by natural transpiration is constructed using a one-pot synthesis. Asymmetric TiO2 micro/nano-structures are integrated onto commercial polyethylene terephthalate (PET) fabric, achieving directional water transport and evaporation performance. The composite dressing offers excellent therapeutic efficacy...

Both poly(vinylphosphonic acid) (PVPA) and sodium trimetaphosphate (STMP), as templating analogs of phosphorylated noncollagenous proteins (NCPs), could induce intrafibrillar mineralization and dentin remineralization via polyelectrolyte-Ca complexes pre-precursor (PCCP) process. This study not only enriches PCCP process with a wider molecular weight...