By controlling the visible-light irradiation time, the correlation between hydrogel stiffness, hyaluronic acid degradation, and endothelial cell behavior is revealed. It demonstrates how changes in hydrogel properties affect human umbilical vein endothelial cells (HUVECs) network formation and highlights the critical role of low-molecular-weight hyaluronic...

An injectable, self-healing hydrogel is presented here, which absorbs near-infrared radiation, offers excellent mechanical properties, biocompatibility, and antioxidant activity, addressing bacterial infections and inflammation in wound healing. Particularly effective against methicillin-resistant Staphylococcus aureus-infected wounds, it stimulates...

A novel biomimetic nanoprodrug MM@CD-PBA-RVT, an amphiphilic CD-PBA-RVT monomer spontaneously assembled nanoprodrug and further camouflaged with macrophage membrane, is exploited to selectively home into the atherosclerotic plaques, accumulate and respond to the pathological reactive oxygen species rich AS microenvironment by locally on-demand drug...

Abstract Immunotherapy based on nanoplatforms is a promising approach to treat cancer and infectious diseases, and it has achieved considerable progress in clinical practices. Cell membrane-based nanoplatforms endow nanoparticles with versatile characteristics, such as half-life extension, targeting ability, and immune-system regulation. However, monotypic...

Abstract Cuproptosis, as a newly identified form of programmed cell death, shows great promise in cancer treatment. Efficient Cu+ delivery while avoiding systemic toxicity and elimination of the resistance from over-expressed intracellular copper chelator glutathione (GSH) are critical for cuproptosis. Herein, we innovatively constructed a biocompatible...

Abstract Early reconstruction of the vascular network is a prerequisite to the effective treatment of substantial bone defects. Traditional 3D printed tissue engineering scaffolds designed to repair large bone defects do not effectively regenerate the vascular network, and rely only on the porous structure within the scaffold for nutrient transfer...