Abstract Immunotherapeutic effect is restricted by the non-immunogenic tumor phenotype and immunosuppression behaviors of tumor associated macrophages (TAMs). In this work, a drug self-assembly (designated as CeBLZ) is fabricated based on chlorin e6 (Ce6) and BLZ945 to activate photodynamic immunotherapy through tumor immunogenic induction and tumor...

Abstract The mitochondrial enzyme arginase-2 (Arg-2) is implicated in the pathophysiology of contrast-induced acute kidney injury (CI-AKI). Therefore, Arg-2 represents a candid target for CI-AKI prevention. Here, we developed layer-by-layer (LbL) assembled renal-targeting polymeric nanoparticles to efficiently deliver small interfering RNA (siRNA),...

Abstract Hydrogels containing chondrocytes have exhibited excellent potential in regenerating hyaline cartilage. However, chondrocytes are vulnerable to dedifferentiation during in vitro culture, leading to fibrosis and mechanical degradation of newly formed cartilage. We propose to modulate cartilage formation via the developed chondrocyte pericellular...

M2 macrophage-derived nanosponges target renal cell carcinoma by enhanced penetration and retention effect, chemokine chemotaxis, and M2-TAMs specific recognition. Highly expressed of CSF-1R, TGF-βR and IL-10R can neutralize the corresponding cytokines. The loaded R848 futher promoted the transformation of M2-TAMs to M1 phenotype, enhanced the anti-tumor...

Abstract Atherosclerosis (AS) management typically relies on therapeutic drug interventions, but these strategies typically have drawbacks, including poor site specificity, high systemic intake, and undesired side effects. The field of cell membrane camouflaged biomimetic nanomedicine offers the potential to address these challenges thanks to its ability...

In this manuscript, thiolation and covalent tethering of IL-33 to the surface of microporous annealed particle (MAP) scaffolds are described to create a bioactive implant (IL33-MAP) that modulates the host immune response. It is found that IL33-MAP scaffolds activate immune cells through the ST2 receptor and recruits type 2 immune cells, which do...